Stem cell treatment for osteoarthritis free#

Stem cell treatment for osteoarthritis free#

Hyaline cartilage is a free of vascular, lymphatic and neural structures. Cartilage consists of four layers - superficial layer, transitional layer, deep layer and layer of calcified cartilage. KeywordsДЄrticular cartilage is hyaline cartilage and is principally composed of water (65-85 %), collagen (10-20 %, collagen type II is 90-95%), proteoglycans (10-20 %) and chondrocytes (1-5 %). Thus, the aim of present review is to clarify the findings associated with MSCs application in the treatment of OA by means of synovial fluid analysis, gait analysis, clinical and x-ray examination often used in veterinary practice.

In addition, they have shown ability to decrease pain and inflammation as well as promote cartilage function and healing in patients with OA. Adult Mesenchymal Stem Cells (MSCs) might serve as an alternative therapy for OA, because they can differentiate into osteo-chondral lineages. Joint supplements, weight management, and rehabilitation therapy often fail to provide a long-term response in inflamed joint. Current therapies, mainly NSAIDs, have many adverse effects and are not able to stop degenerative process. This state is irreversible and actual conventional therapies are not able to provide regeneration of damaged tissue.

Osteoarthritis (OA) is Degenerative Joint Disease (DJD) associated with pain, inflammation and cartilage degradation resulting in lameness.